Pathology of Stenotic Lesions of the Small Intestine Minako Hirahashi 1,2 1Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University 2Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Keyword: 小腸狭窄 , , 悪性リンパ腫 , Crohn病 , 狭窄型虚血性小腸炎 pp.1699-1706
Published Date 2016/12/25
DOI https://doi.org/10.11477/mf.1403200789
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 Here we describe the histopathological features of small intestinal stenotic diseases, such as cancer, malignant lymphoma, Crohn's disease, and ischemic stenosis. Neoplasms typically show severe annular stenosis with epithelial dysplasia, and histologically, a severe desmoplastic reaction accompanied by the invasion of cancer cells is observed. On the other hand, in malignant lymphoma, the small intestinal wall is markedly thickened by the proliferation of lymphoma cells, with small desmoplastic reaction, and shows shallow ulcers with annular stenosis. Crohn's disease results in lateral stenosis with longitudinal ulcer on the mesenteric site and is often accompanied by deep and narrow fissuring ulcers. Ischemic stenosis of the small intestine is characterized by concentric tubular stenosis involving the entire circumference and segmental ulcers. Histologically, vascular-rich granulation tissue, marked fibromusculosis, and fibrosis are observed in the submucosa, accompanied by a relatively severe chronic inflammatory infiltrate.

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