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Bisphosphonate (Alendronate): Induced Esophagitis Observed by Endoscopy, Report of a Case Yoshiyuki Ito 1 , Yukiko Kuroda 1 , Takashi Uchiyama 1 , Takaya Saito 1 , Shigeji Ito 1 , Yasuharu Kaizaki 2 1Division of Internal Medicine, Tannan Regional Medical Center, Sabae, Japan 2)Department of Pathology, Fukui Prefectural Hospital, Fukui, Japan Keyword: 薬剤性食道炎 , ビスフォスフォネート製剤 , 服薬指導 pp.193-197
Published Date 2015/2/25
DOI https://doi.org/10.11477/mf.1403200151
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 A 69-year-old woman was admitted to our hospital because of severe retrosternal pain, odynophagia, heartburn, and body weight loss. She had been generally well until a week before admission. Endoscopic examination revealed demarcated shallow esophageal erosions at 30〜35 cm from the incisors, with normal adjacent mucosa. Pathological examination of the biopsy specimen showed inflammatory exudates and inflamed granulation tissue accompanied with massive eosinophilic infiltration. The patient reported receiving alendronate for 3 years as a treatment for post-menopausal osteoporosis and had taken the tablet without adequate water 4 days before onset. Therefore, erosions were believed to be because of alendronate intake, and alendronate-induced esophagitis was diagnosed. All symptoms had immediately resolved by a temporary period parenteral hydration and administration of intravenous H2-receptor antagonist and oral antacids. Ten days after admission, repeated endoscopic examination demonstrated ulcer healing. It is important to perform endoscopy immediately for accurate diagnosis. Moreover, we would like to emphasize the importance of providing proper instructions to minimize the risk of serious side effects of bisphosphonates.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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