胃癌の癌深達率についての病理組織学的研究

Histopathological Study on Depth Invasion of Gastric Cancer

　一般的に，胃体上部の癌は小さいながらも進行癌であり，また，粘膜内における癌病巣の拡がりは粘膜下層における拡がりに比べてきわめて小さい場合が多い^1)～4)．一方，幽門前庭部における癌の粘膜内の拡がりと粘膜下組織以下の層における拡がりはほぼ同じである場合が多い^1)～4)．これらのことから胃体部の胃癌は粘膜下層へ浸潤しやすい傾向があるのではないかと考えられる．

　この研究の目的は胃癌の組織型および占拠部位別にみた癌の胃壁深達についての検討である．

　As compared with cancer of the pyloric antrum, that of the body tends to reach the serosal layer easily. Thus, it is considered that gastric body cancer has a tendency to penetrate the muscularis mucosae more easily than pyloric antrum one.

　We have studied the rate of invasive cancer foci which shows how many cancer foci invade beyond the muscularis mucosae in relation to size, location and histological type of cancer.

　Conclusions are as follows ;

　(1) Undifferentiated gastric cancers arising in the body far more easily invade beyond the muscularis mucosae even when the tumor is small (less than 2.0 cm in diameter) than differentiated ones of the body and any type of cancers of the pyloric antrum.

　(2) The rate of vertical invasion in differentiated and undifferentiated gastric cancer of the pyloric antrum showed a similar tendency. Therfore, the rate is considered to be more related to the size of cancer than to histological type in cancers of the pyloric antrum.