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Two Cases with Familial Adenomatosis of the Colon, Associated with Multiple Polypoid Lesions of the Stomach, Duodenum and Upper Jejunum M. Iida 1 , T. Yao 1 , T. Omae 1 , K. Ohsato 2 , H. Watanabe 3 , H. Horinouchi 4 1The Second Department of Internal Medicine, The Faculty of Medicine, Kyushu University 2The First Department of Surgery, The Faculty of Medicine, Kyushu University 3The Second Department of Pathology, The Faculty of Medicine, Kyushu University 4The Section of Internal Medicine, Red Cross Hospital pp.227-234
Published Date 1977/2/25
DOI https://doi.org/10.11477/mf.1403112486
  • Abstract
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 Two cases with familial adenomatosis of the colon (polyposis coli), associated with multiple polypoid lesions of the stomach, duodenum and upper jejunum are described in reference to those reported in the literature.

 Case 1 (negative family history):

 A 41-year-old woman had suffered from diarrhea and weight loss for several months.

 Gastric X-ray examination revealed numerous polypoid lesions in the gastric body and antrum, suggesting that she might have polyposis coli, which was proved by barium enema. Upper GI series and endoscopic examinations demonstrated multiple polypoid lesions in the stomach as well as duodenum and jejunum.

 Histological studies of the biopsy specimens from polypoid lesions of the gastric body showed the fundic mucosal hyperplasia with cystic dilatations. On the other hand, all specimens from the gastric antrum, duodenum and jejunum disclosed that these poly poid lesions were adenoma in origin.

 Case 2 (positive family history):

 A 26-year-old man had a history of partial gastrectomy for duodenal ulcer in 1969. Upper GI series and endoscopic examinations revealed multiple small polypoid lesions in the remaining stomach, duodenum and upper jejunum. Polypoid lesions in the unresected part of the stomach were shown to be fundic mucosal hyperplasia, whereas those of the duodenum and jejunum were adenomas.

 Both patients had total colectomy. Resected specimens of the colon showed a typical picture of poly-posis coli associated with advanced cancers.


Copyright © 1977, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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