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Familial Polyposis of the Colon: A study on upper gastrointestinal lesions and infantile onset M. Iida 1 , T. Yao 1 , S. Fuyuno 1 , T. Omae 1 , H. Watanabe 2 , K. Ohsato 3 1The Second Department of Internal Medicine, Faculty of Medicine, Kyushu University 2The Second Department of Pathology, Faculty of Medicine, Kyushu University 3The First Department of Surgery, Faculty of Medicine, Kyushu University pp.1241-1250
Published Date 1975/9/25
DOI https://doi.org/10.11477/mf.1403112320
  • Abstract
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 This report is based on two families in which 2 adults (41 and 38 years old) and 3 children (11, 8 and 8 years old) developed polyposis of the colon and upper gastrointestinal tract.

 In all of 5 cases numerous small sessile polyps were noted in the duodenum. Histological examination performed on 3 cases revealed all polyps to be adenoma. Multiple sessile polyps were found in the gastric antrum in 4 cases. Histological examination on 2 cases showed all gastric polyps to be adenoma as well. Careful upper gastrointestinal survey including hypotonic duodenography and fiberscopy is necessary to find these small lesions in the duodenum.

 The polyps of the colon in 3 children, histologically adenoma, were found as tiny sessile lesions scattered in the sigmoid and descending colon. But polyps were hardly recognized in the rectum. These results suggest that these iufantile cases could be missed by sigmoidoscopy alone, which has been described to be an adequate examination for this purpose.

 Two adult cases had the characteristic findings of familial polyposis of the colon; diffuse polyposis and colonic cancers, quite distinct from those seen in the children. On the other hand, upper gastrointestinal lesions in adult cases consisted of small sessile polyps, similar to those seen in the infantile cases and showed no malignant change. Therefore, the associated upper gastrointestinal lesions may develop as early as colonic lesions, but the former may have slower growth and fewer malignat changes.

 Gardner's stigmata were also recognized in 3 cases. These findings suggest that this disease should not be regarded as a localized disease of the colon, but as a systemic disease with a predisposition to multiple tumor formation.


Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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