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Gastric and Duodenal Lesions Associated with Familial Polyposis Coli K. Ushio 1 , M. Sasagawa 1 , T. Yamada 1 , H. Ichikawa 1 1Dept. of the Diagnostic Radiology, National Cancer Center Hospital pp.1547-1557
Published Date 1977/11/25
DOI https://doi.org/10.11477/mf.1403112489
  • Abstract
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 Gardner's syndrome (a familial disease characterized by colonic polyposis, osteomatosis and soft tissue tumor) and familial polyposis coli have two theories for the pathogenesis. One is that they are caused by different gene ; and the other is that both originate from the same single gene. We have attempted to examine the stomach, doudenum, bones, teeth and other lesions on 30 cases in 14 pedigrees of familial polyposis coli not accompanied by distinct masses in appearance. The following results were obtained : (1) Accompanying polypoid lesions of the stomach were observed in as many as 17 of 27 cases (63.0%). (2) Polypoid lesions of the stomach were classified into two groups : one was the fundic glandular lesion showing localized simple hypertrophic change and the other was the pyloric glandular lesion showing “atypical epithelium”. (3) Accompanying flat polypoid lesions of the duodenum were observed in 12 out of 13 cases, and adenoma were found in 9. (4) Of 22 patients whose bones were examined, small osseous abnormalities such as osteoma, exostosis and cortical thickening were accompanied in 11 cases (50%). (5) Orthopantomagraphy was carried out in 23 cases and multiple osteosclerotic lesions of the mandible and maxilla were observed in 20 (87%). (6) A high percentage of abnormalities of the teeth were also observed. (7) Epidermal cysts were observed in 3 cases. And gastric cancer, thyroid cancer, adrenal adenoma, or mesenteric desmoid tumor was discovered in one case respectively. (8) Between the cases accompanied by osseous changes (Gardner's syndrome) and those which were not accompanied by them (familial polyposis coli), there was no distinct difference in the number and size of polyps in the large intestine, duodenum, stomach and other tumor lesions.

 These facts have shown us that there exists no distinct qualitative difference between the two diseases. Conclusively these two disease entities are the same systemic disease with a predisposition to multiple tumors formation and they both should be called as “familial gastrointestinal polyposis syndrome”.


Copyright © 1977, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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