胃ポリープの臨床病理学的検討

Clinico-pathological Study of Gastric Polyp

　胃ポリープ，とくに腺腫性ポリープの病理形態像に関しては多くの研究があり，その発生機序は徐々に解明されつつあるが，いまだ不明の点が多い．われわれはすでにできあがった腺腫性ポリープについて臨床病理組織学的立揚から検討を行ない，腺腫性ポリープの性状ならびに分類について2，3の成績を得たので報告する．

研究対象および研究方法

　昭和32年1月より昭和45年12月までの14年間に信州大学第2外科で胃切除ないしポリープ切除を施行した腺腫性ポリープ40例，ポリープ数にして133個を研究対象とした．おのおのポリープについて，ヘマトキシリン・エオジン染色およびPAS-Heidenhain鉄ヘマトキシリン重染色による組織標本を作製し，組織学的検索を行なった．

　Clinico-pathological study was carried out on 40 cases of adenomatous gastric polyp removed surgically. The age of patients with single polyp varied from 20 to 50, while those with multiple polyps were seen over the age of 50. Solitary polyp was mostly located in the pyloric antrum and multiple ones were widely extended from the pyloric antrum to the body. The polyps were histologically classified as foveolar cell type, pyloric gland type and mixed type. Those of foveolar cell type were observed in both the pyloric and fundic gland areas, while those of pyloric gland type were seen only in the pyloric gland area.

　Mucus secretion of the polyps was studied with PAS stain indicating neutral polysaccharide. The foveolar cell type showed slight to accelerated degree of mucus secretion and the pyloric gland type showed only slight degree of it. The mucus secretion of the foveolar type was analyzed in more details and it was revealed that those arising in the fundic gland area secrete mucus more than those that arose in the pyloric gland area.