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Japanese

A Histopathological Study of Barrett's Esophagus with Special Reference to the Specialized Columnar Epithelium Shin-ichi Nakamura 1 , Isamu Kino 2 , Tomio Arai 3 1Department of Pathology, Hamamatsu University Hospital 2The First Department of Pathology, Hamamatsu University School of Medicine 3Department of Pathology, Fujieda City General Hospital Keyword: Barrett食道 , Barrett上皮 , 腸上皮化生 , 円柱細胞 , goblet cell pp.425-432
Published Date 1990/4/25
DOI https://doi.org/10.11477/mf.1403110632
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 Literature review was made on Barrett's esophagus, in particular, on morphological characteristics of the columnar epithelium (Barrett's epithelium). Histopathological findings in two cases we experienced were presented as well. We compared the specialized columnar epithelium (SCE) of Barrett's esophagus, which have been thought to be pathognomonic for this disease, with the epithelium of gastric intestinal metaplasia. Morphological study as well as mucin histochemistry and immunohistochemistry indicated that SCE had similar characteristics to the epithelium of gastric intestinal metaplasia.

 The SCE of Barrett's esophagus has been considered morphologically distinctive from the normal lining epithelium of the gastrointestinal tract. According to our studies, however, SCE is not distinguished from the epithelium of gastric intestinal metaplasia, which is commonly seen but not considered as specialized epithelium.

 We stress here that one should not use the term "specialized columnar epithelium", because it is not specialized and it may provoke misunderstanding and confusion in the study of pathogenesis of Barrett's esophagus.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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