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Morphopathologic Features of Refractory Gastric Ulcer: New Concepts of the Healing Process and Intractability of Gastric Ulcer Hidenobu Watanabe 1 1The First Department of Pathology, Niigata University School of Medicine Keyword: 胃潰瘍 , 難治性胃潰瘍 , 治癒過程 , 間葉変化 , 内側線維症 , 外側線維症 pp.1423-1434
Published Date 1992/12/25
DOI https://doi.org/10.11477/mf.1403110197
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 Histological factors that affect the healing of gastric ulcers are regenerative epithelium and mesenchymal tissue. This healing process consists of the following important factors: reduction in ulcer size, and elevation and shallowing of an ulcer base by mesenchymal tissue, as well as covering of the ulcer by regenerative epithelium, and favorable histologic change in mesenchymal tissue and regenerative epithelium with time. Research on mesenchymal tissue is not as advanced as that on regenerative epithelium. We were the first researchers to demonstrate sequential changes in mesenchymal tissue in ulcer healing. There are inner and outer fibrosis which have an important role in reduction of ulcer size, and elevation and shallowing of the ulcer base. An inner fibrosis consisting of myofibroblasts and fibroblasts develops into collagenomusculosis and at last into musculosis, forms a muscle layer fusion and thick muscularis mucosa, and stay in the tissue chronically. On the other hand, outer fibrosis tends to be collagen bands (collagenosis) which disappear later. We discuss the morphological characteristics of refractory gastric ulcers based on our new findings.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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