Study on Endoscopic Findings of Intractable Gastric Ulcer: Factors Influencing Healing Rateand Long-term Prognosis Katsunori Saigenji 1 , Toshiharu Mitsuhashi 1 , Takeshi Ashihara 1 , Tomoya Kan 1 , Masahito Ohida 1 , Severino Marcos 1 , Borba de Arruda 1 1Department of Internal Medicine, Kitasato University, School of Medicine Keyword: 胃潰瘍 , 難治性胃潰瘍 , H2ブロッカー , 長期経過 pp.251-262
Published Date 1993/3/25
DOI https://doi.org/10.11477/mf.1403106110
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 The aim of this study was to evaluate the characteristics of intractable gastric ulcers under treatment with H2-receptor antagonist. Background factors and endoscopic findings of tractable (healed within 4 weeks) and intractable (not healed after 12 weeks of treatment) gastric ulcers were compared with chisquare test.

 Background factors were as follows: age, sex, location and shape of ulcer, ulcer history, duration of symtoms, concurrent duodenal ulcer, smoking, and alcohol consumption.

 Endoscopic findings in the active and healing stage were also used for evaluation of intractable factors.

 Cumulative healing rate with H2-receptor antagonist was 39.3% at 4 weeks, 79.6% at 8 weeks and 90.0% at 12 weeks in 581 patients of gastric ulcers.

 In 456 patients treated from the active stage, cumulative healing rate was 38.0% at 4 weeks, 75.9% at 8 weeks and 87.6% at 12 weeks respectively. Most intractable gastric ulcers were deep excavated ulcers surrounding amarked elevation located in the angle.

 Other factors involved in intractable ulcer were recurrent cases, long duration of symptoms and smoking habit.

Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.


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