Histogenesis of Undifferentiated Carcinoma Observed in Experimentally Induced Gastric Cancer in Dogs Toshiki Kamano 1 , Noriyuki Kuwabara 2 , Kazuhiro Taki 2 , Ken Mizukami 1 , Noboru Azuma 1 pp.171-176
Published Date 1986/2/25
DOI https://doi.org/10.11477/mf.1403110099
  • Abstract
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 To induce colorectal cancer, suppositories containing 50mg of N-ethyl-N'-nitro-N-nitrosoguanidine(ENNG)were consecutively administered to dogs intrarectally. As a result, advanced colorectal cancer and minimal multiple undifferentiated carcinomas in the stomach developed in two mongrels. Their whole stomachs were sectioned serially in the width of 6μm, stained with H・E, PAS-Alcian blue and Pentachrome, and investigated on histogenesis of undifferentiated carcinoma. This investigation showed that many minimal signet-ring cell carcinomas occurred at the fundic gland, especially around the glandular neck and that cancer fell directly from the glandular lumen to the propria mucosae. But there was no atrophy of ordinary gland, and the so-called “double-layer structure”could not be detected(Figs. 4-10). These findings may be very interesting ones for the study of histogenesis of human undifferentiated carcinomas.

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