Present Status of Endoscopic Therapy for Gastric Cancer Mainly by Laser Irradiation Y. Okazaki 1 1The First Department of Internal Medicine, Yamaguchi University, School of Medicine pp.885-894
Published Date 1984/8/25
DOI https://doi.org/10.11477/mf.1403109573
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 Authors studied the development of endoscopic therapy for gastric cancer mainly by laser irradiation and evaluated its present status and problems.

 Laser therapy today includes photocoagulation mainly with the use of Nd-YAG laser and photodyna-mic therapy which is done in combination with the light sensitivity materials with tumor affinity and Argon laser or Dye laser. For the nest of early gastric cancer, photocoagulation is advantageous by using Nd-YAG laser with strong light energy and can put cancer cells within the submucosal layer into coagulation necrosis. On the other hand, it is dangerous to use Nd-YAG laser for the nest of advanced gastric cancer because irradiation to deeper layer has risk of perforation. Photodynamic therapy is advantageous at this point in destroying only cancer cells without any influence to the normal tissue. Therefore, it is possible to perform safely the therapy for the cancer tissue infiltrating to the proper muscle or subserosa. However, there are some problems, that is, it needs long time laser irradiation and has side effects such as dermatitis solaris caused by light sensitive material by hematoporphyrin derivative.

 Endoscopic therapy for gastric cancer using laser irradiation has just been put into practice and has now yet limitation in its indication. But what is important is the recognition that laser therapy is a specific therapy which is impossible to perform without laser endoscopy. The development of laser therapy from now on depends on how endoscopists think about this problem.

Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.


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