雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Systemic AA Amyloidosis Associated with Undetermind Inflammatory Bowel Disease, Report of an Autopsy Case Masahiro Tanaka 1 , Ken Saito 3 , Makio Hatakeyama 2 , Takako Yamaguchi 3 , Hiroyoshi Arai 1 1Department of Gastroenterology, Jichi Medical School 2Department of Collagen Disease, Jichi Medical School 3Department of Pathology, Jichi Medical School pp.151-158
Published Date 1988/2/25
DOI https://doi.org/10.11477/mf.1403107880
  • Abstract
  • Look Inside

 The case reported here was a 32-year-old female who first noticed fever and abdominal pain at the age of 27 years. Bloody diarrhea occurred at the age of 29 years, followed by proteinuria. X-ray study revealed loss of haustra and diffuse luminal narrowing of the left colon. Rectal biopsies showed mucosal inflammation with crypt abscesses and scattered amyloid globules. Mild amyloidosis was also demonstrated on renal biopsy. Salazopyrin, administered under the diagnosis of ulcerative colitis, induced disappearance of mucosal inflammation and amyloid globules, relieving intestinal symptoms and proteinuria. She was free of intestinal symptoms for the subsequent two years. Three months after Salazopyrin was reduced in dose, intractable bloody diarrhea and marked proteinuria developed. Sequential GI tract biopsies revealed further advanced mucosal amyloidosis. She died of subileus complicated by pneumonia and renal insufficiency at the age of 32 years, 6 years after the initial symptom had appeared.

 Systemic AA amyloidosis involving in particular, GI tract mucosa and shortening of the entire intestine was demonstrated by autopsy. Similar clinicopathologic features in a 34-year-old female was reported by Targgart et al in 1963.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有