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Recurrence of Early Gastric Carcinoma: A cytophotometric DNA analysis T. Okamura 1 , K. Inokuchi 1 , T. Kamegawa 1 , D. Korenaga 1 , R. Kumashiro 1 , O. Sasaki 2 , Y. Kodama 3 1The Second Department of Surgery, Faculty of Medicine, Kyushu University 2Department of Surgery, Fukuoka Dental College 3The Second Department of Surgery, School of Medicine, Fukuoka University pp.755-761
Published Date 1984/7/25
DOI https://doi.org/10.11477/mf.1403109516
  • Abstract
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 A cytophotometric DNA analysis was performed in 108 cases of early gastric carcinoma according to the growth patterns. DNA distribution pattern was classified into types Ⅰ, Ⅱ, Ⅲ and Ⅳ, according to the degree of dispersion on the DNA histogram. The majority of Super (superficially spreading) type, which showed quite excellent prognosis of the patient, were type Ⅱ (high peak at 2 to 4 c ranges with a narrow scatter). On the contrary, Pen A (expansively penetrating growth) type, which had a poor prognosis of the patient due to early recurrence in the liver, showed types Ⅲ or Ⅳ (low or no peak with a wide scatter and an increase of cells over 6c) in the majority of cases. Most of the Pen B (infiltratively penetrating growth) type and the Small mucosal type (not classifiable into the Super or the Pen types), both of which had an excellent prognosis of the patient, were type Ⅱ. All five cases of normal gastric mucosa were type Ⅰ. Thus, there was a distinct difference in the DNA distribution pattern between Super and Pen A types. This would suggest that cancer cells of the Super type may have a low grade malignancy whereas those in Pen A type a high grade malignancy. Among 12 cases of the Small mucosal type with type Ⅳ, two recurrent cases were died after five years postoperatively. This suggests the existence of a highly malignant prototype of the Pen A type.

 Thus, an analysis of the DNA distribution pattern may be useful for detection of early gastric carcinomas of high grade malignancy in the early stages of development.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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