Pathomorphological Change of Intestinal Behçet's Disease and Simple Ulcer Tamaki Ohta 1 , Hidemobu Watanabe 1 , Yoichi Ajioka 1 , Hiroyuki Ishikawa 1 1The First Department of Patholigy, Niigata University School of Medicine Keyword: 腸型Behçet病/腸simple ulcer , 病理形態の推移 , 急性型/慢性活動型 pp.276-285
Published Date 1992/3/25
DOI https://doi.org/10.11477/mf.1403106748
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 Twenty-four surgical cases with intestinal Behçet's disease and/or simple ulcer were examined in order to study morphological change of the intestinal ulcers with medical therapy and time. All the ulcers examined histologically were 202, and their depth were Ul-Ⅰ in 4, Ul-Ⅱ in 64, Ul-Ⅲ in 66 and Ul-Ⅳ in 68 ulcers, The phases of the 202 ulcers were devided into three types; acute type in 21, chronic active type in 122 and healed type in 59 ulcers. Two pathways of the development of chronic active ulcer are supposed; one is chronic transformation from acute ulcer and the other is ab initio chronic active ulcer. Chronic active Ul-Ⅳ ulcer is supposed to develop from shallow chronic active ulcers on many occasions and from acute Ul-Ⅳ ulcers on some occasions. Deepening and incurability of chronic active ulcer is due to persistence of chronic inflammatory cell infiltration mainly composed of lymphocytes and plasma cells on the ulcer base. It is completely different from histological findings of gastric peptic ulcer largely related to gastric acid.

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