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Clinical Features and Diagnostic Imaging of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Kyosuke Ushio 1 1Department of Diagnostic Radiology, National Cancer Center Hospital Keyword: HNPCC , 画像診断 , 自然史 , 結節集簇様病変 , 泌尿器癌 pp.831-840
Published Date 1996/6/25
DOI https://doi.org/10.11477/mf.1403104166
  • Abstract
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 Patients with HNPCC may develop gastric cancer, endometrial cancer, ovarian cancer, or urogenigal cancer besides colorectal cancer. We report HNPCC cases with these lesions from the diagnostic imaging viewpoints. Regular family history taking of the patients with HNPCC for more than ten years revealed a difference of tumor development among the generations tumors in the HNPCC family may be found earlier in their age as the generation goes. Regular family history taking would be essential for the diagnosis of HNPCC. The development and extension of HNPCC were evaluated retrospectively and the results were summarized as follows: 1) Most of the initial lesion were found to be the sessile elevated type (type Ⅰs), superficial elevated type (type Ⅱa), or superficial elevated and depressed type (type Ⅱa + Ⅱc). 2) Doubling time of the lesion which developed advanced cancer in the HNPCC was 12.0 months, whereas that in the usual colorectal cancer was 11.1 months. There was no statistical difference between the two doubling times. Therefore, natural history of the colorectal lesion in the HNPCC may be the same as that in the usual colorectal cancer.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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