Distribution of Epithelioid Granuloma and Macroscopic Findings in Crohn's Disease Tadakazu Shimoda 1 1Department of Pathology, Division of Clinical Laboratory, National Cancer Center Hospital Keyword: Crohn病 , 類上皮肉芽腫 pp.505-512
Published Date 1996/3/25
DOI https://doi.org/10.11477/mf.1403104113
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 The relationship between epithelioid granuloma and ulcers, and distribution of granuloma by the depth of the bowel wall were evaluated. The results were summarized as follows. The incidence of epithelioid granuloma in the mucosa was low. Most epithelioid granulomas were located in the submucosa, especially adjunct to the muscular layer of mucosa. The rest of them were located in the tunica muscularis propria or submucosal layer. Epithelioid granuloma may be found less than 20 mm in length from an ulcer. Therefore, it may be important to biopsy specimens deeper than the muscular layer of mucosa. Epithelioid granuloma was not pathognomonic for Crohn's disease its distribution and macroscopic findings may help to make a diagnosis of Crohn's disease.

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