Long-term Clinical Course of Crohn's Disease: Study on Changes of Lesions in Radiological Findings in Cases Followed-up More Than 10 Years Hidehisa Ohi 1 , Yishito Nishimata 1 , Hiroto Nishimata 1 1Department of Gastroenterology, of Nanpu Hospital Keyword: Crohn病 , 長期経過 , 敷石像 , 縦走潰瘍 , 血流障害 pp.1227-1238
Published Date 1999/9/25
DOI https://doi.org/10.11477/mf.1403102816
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 On patients with Crohn's disease in eighty-three patients with Crohn's disease, in which the clinical course could be observed well at our clinic from April 1972 to April 1999, we studied the probability rate of need for surgery and chronological changes inradiological findings. Four patients among a total of 83 patients died, and five patients were complicated with amyloidosis. The probability that surgery would be needed five, ten and fifteen years after onset of symptoms was 30.3%, 45.5% and 73%, respectively. Our data shows that the probability that a further operation would be needed three, five and ten years after the first operation was 12.5%, 43.5% and 69.2% respectively. Recurrence caused by cobblestone appearance and longitudinal ulcer on the non-resected small bowel was recognized in 11 of 23 patients. 8 patients (73%) of these 11 patients received a second resection. In 17 cases in the small intestine and 12 cases in the large intestine cobblestone appearance was visualized in radiographic findings, 8 cases of 17 cases and 6 cases of 12 cases developed into narrowing, stenosis and formation of fistulas and required surgery.

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