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要旨 早期胃癌に対する内視鏡的粘膜下層剝離術(ESD)は広く普及し,Helicobacter pylori除菌療法はその後の標準治療となった.今回当院でESD後除菌成功後に認めた異時性多発胃癌を検討した.2000年から2010年までのESD治癒切除症例で,その後H. pylori除菌療法成功後に異時性胃癌を認めたものが合計33例39病変存在した(2次癌33病変,3次癌6病変).除菌後胃癌発見までの期間は平均28.8か月,中央値15.0か月(5~120か月),男女比 31/2,腫瘍径中央値12.3(3~30)mmであった.発見時検査と前回検査との間隔は平均8.5(5~19)か月であった.陥凹型で分化型の粘膜内癌の頻度が高く,高度萎縮粘膜の患者頻度が高かった.今後は長期経過例の症例蓄積が必要である.
Endoscopic submucosal Dissection(ESD)for early gastric cancer has become widespread in Japan and eradication therapy for Helicobacter pylori has become a standard treatment after ESD. In this study, we analyzed metachronous gastric cancer(MGC)after ESD and successful eradication therapy. 39lesions(33 second and 6 third lesions of gastric cancer)were detected as MGC in 33 patients after ESD and successful eradication therapy. The time to detection for secondary gastric cancer was 28.8 months on average, 15.0 months in median(range 5-120). Male/female ratio was 31/2, and the median size of MGC was 12.3mm(range 3-30). The interval between the time of detection for MGC and the time of the last examination was 8.5(5-19)months. Most of the MGC were the depressed type, intramucosal cancer and existed with severe gastric atrophy. For further analysis, we have to do long term follow up in patients after ESD.
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