Development and Progression of Colorectal Cancer─Histopathological View Yasuo Ohkura 1 1Department of Pathology, Kyorin University School of Medicine, Tokyo Keyword: 大腸癌 , 組織発生 , 発育進展 , adenoma-carcinoma sequence , de novo発生説 pp.624-630
Published Date 2010/4/30
DOI https://doi.org/10.11477/mf.1403101912
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 The adenoma-carcinoma sequence and the de novo cancer theory are two major theories of the carcinogenesis of colorectal cancer. In this paper the historic change in those opinions are reviewed. We examined 347 cases of early colorectal cancers histopathologically, and estimated the carcinogenesis and developmental process of colorectal cancers are estimated. Most cases of M cancers were carcinoma with adenoma components. On the other hand, 59% of cases of SM cancers were carcinoma without adenoma. In 63 cases of SM cancers, which were non-pedunculated, less than 3cm in size and with invasion depth of more than 1,000μm, 68% of cases were carcinoma without adenoma, and 79% of cases had arisen from superficial type carcinoma. From the data obtained, it is considered that the de novo cancers of superficial type are the major lesions that develop into advanced cancers.

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