Adenoma-Carcinoma Sequence and De Novo Cancer Theory for the Carcinogenesis in Colorectal Carcinomas Yusuke Saitoh 1 , Motoya Tominaga 1 , Kenichiro Ozawa 1 , Yoko Kikuchi 1 , Satoshi Suzuki 1 , Ryuji Sukegawa 1 , Kazuya Koizumi 1 , Atsushi Chiba 1 , Masaki Taruishi 1 , Jiro Watari 2 , Mikihiro Fujiya 3 1Digestive Disease Center, Asahikawa City Hospital, Asahikawa, Japan 2Department of Gastroenterology, Kushiro Medical Association Hospital, Kushiro, Japan 3Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan Keyword: adenoma-carcinoma sequence , de novo癌説 , 大腸腺腫 , 表面型早期大腸癌 pp.1891-1896
Published Date 2008/12/25
DOI https://doi.org/10.11477/mf.1403101533
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 There are two theories for the carcinogenesis of the colorectal carcinomas. The one is adenoma-carcinoma sequence that all the colorectal carcinoma is arose from benign adenomas and the other is de novo cancer theory that the most colorectal carcinomas arose from normal colonic mucosa not via adenomas. Adenoma-carcinoma sequence is currently recognized true as a carcinogenesis of the colorectal carcinomas, internationally. On the other hand, many flat and depressed early colorectal carcinomas have been detected in Japan from around 1990. There is no concomitant adenoma component in flat and depressed type early carcinomas so that the most flat and depressed type early carcinomas are thought as de novo cancers in Japan. In order to elucidate whether adenoma-carcinoma sequence or de novo cancer theory is the main route of carcinogenesis in colorectal carcinomas, there will be required that histopathological criterion for the diagnosis of adenoma and adenocarcinoma between Japanese and western pathologists is standardized and recognition and the incidence of flat and depressed type early carcinomas is internationally revealed.

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