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Differential Diagnosis and Treatment of Collagenous Colitis Kiyotaka Okawa 1 , Wataru Ueda 1 , Koji Sano 1 , Takehisa Suekane 1 , Soichi Sano 2 , Ayako Tanaka 2 , Keiko Yamagami 2 , Katsunori Yoshioka 2 , Yuki Kubo 3 , Ken Inoue 3 , Saori Matsui 4 , Hideto Oiya 5 , Tetsuya Aoki 6 1Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan 2Department of General Medicine, Osaka City General Hospital, Osaka, Japan 3Department of Pathology, Osaka City General Hospital, Osaka, Japan 4Department of Gastroenterology, Yodogawa Christian Hospital, Osaka, Japan 5Oiya Clinic, Kawachinagano, Japan 6Internal Medicine, Osaka City Sumiyoshi Hospital, Osaka, Japan Keyword: collagenous colitis , collagen band , 縦走潰瘍 , mucosal tears , 慢性下痢 pp.2006-2017
Published Date 2009/12/25
DOI https://doi.org/10.11477/mf.1403101819
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 We examined the clinical and endoscopic features, treatments, and other characteristic of 8 patients with collagenous colitis(CC)in our department, with considerations of differential diagnosis and treatment. Endoscopic abnormalities were found in 6 of the 8 patients. Decreased vascular permeability, which had the highest incidence, was observed in 6 patients, easy bleeding and vascular growth and longitudinal ulcers/ulcer scars in 3, and transverse ulcers/ulcer scars in 1. Endoscopy-induced mucosal tears were found in 2 patients, and a characteristic long longitudinal ulcer in 1. The patients with longitudinal ulcers were suspected to have ischemic colitis, and one patient with decreased vascular permeability and easy bleeding was suspected to have amyloidosis, leading to the taking of a biopsy specimen. Four other patients were suspected to have CC based on endoscopic features, and they also underwent biopsies. Five patients obtained clear remission of symptoms with drug discontinuation, and each of them had been treated with lansoprazol. Symptoms in one patient did not resolve with the discontinuation of lansoprazol and NSAID. Because the symptoms were accompanied by marked protein loss, prednisolone was administered, which led to remission of symptoms. The abnormalites in two other patients were not associated with drug administration.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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