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Clostridium Difficile Infection Takayuki Matsumoto 1 , Ritsuko Fujisawa 1 , Shuji Kochi 1 , Katsuya Hirakawa 2 , Kohji Ikegami 2 , Minako Hirahashi 3 , Mitsuo Iida 1 1Department of Medicine and Clinical Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan 2Division of Gastroenterology, Fukuoka Red Cross Hospital, Fukuoka, Japan 3Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Keyword: Clostridium difficile , 偽膜性大腸炎 , 大腸内視鏡 pp.1629-1636
Published Date 2008/10/25
DOI https://doi.org/10.11477/mf.1403101492
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 We reviewed recent advance in the diagnosis and the management of Clostridium difficile infection. While Clostridium difficile has been regarded as one of the major causes of nosocomial infection following the use of antibiotics, asymptomatic carriers and outbreaks of the infection have recently been drawing much attention. Clostridium difficile-associated disease(CDAD)is clinically classified into that of asymptomatic carriers, simple antibiotic-associated diarrhea, diarrhea without pseudomembrane formation, pseudomembranous enterocolitis, and fulminant colitis. It has also been reported that the infection is associated with the deterioration of inflammatory bowel disease. Although pseudomembranous colitis can easily be diagnosed through the patients' history and colonoscopic findings, toxins of the bacteria should be proven for the diagnosis of other types of the infection. Either oral metronidazole or vancomycin is the first choice for the management of infection. In cases of intractable or recurrent infections, tapered-pulsed vancomycin with concomitant probiotics or toxin-binding compounds is recommended.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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