Esophageal Squamous Papilloma, Report of Two Resected Cases Miwako Arima 1 , Masahiro Tada 1 , Junko Aida 2 1Department of Gastroenterology, Saitama Cancer Center, Saitama, Japan 2Division of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Keyword: 食道乳頭腫 , 食道表在癌 , 拡大内視鏡 pp.305-309
Published Date 2008/3/25
DOI https://doi.org/10.11477/mf.1403101293
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 Progress in endoscopic devices has facilitated the detection of esophageal squamous papilloma, previously considered rare. Esophageal squamous papilloma most frequently arises in the lower esophagus, but can also occur in the middle or upper esophagus. Esophageal squamous papilloma is thought to be caused by chronic stimulation due to reflux esophagitis in association with esophageal hiatal hernia. The causal relation between esophageal squamous papilloma and human papilloma virus(HPV)remains controversial; however, the incidence of esophageal squamous papilloma caused by HPV is considered low. Histopathologically, esophageal squamous papilloma consists of a thin interstitium surrounding blood vessels and hyperplastic papillary proliferation of stratified squamous epithelium, rarely associated with atypia. The use of magnifying endoscopy permits detailed observation of vascular structures, allowing smaller papillomas to be detected. Esophageal squamous papilloma has a sea anemone-like appearance with a finely lobulated, translucent, white surface or a hemispheric mulberry-like appearance. Magnifying endoscopy revealed micro vessels in the middle of each lobulated process. In the lower esophagus, some lesions were red;dilated, tortuous micro vessels were observed in each granule. Esophageal squamous papilloma associated with superficial esophageal cancer is extremely rare. To our knowledge, only 3 cases have been reported.

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