Synchronous Triple Malignant Tumors in the Esophagus,Lung and Small Intestine, Report of a Case Suketo Sou 1 , Takashi Nagahama 1 1Department of Gastroenterology, Shin-Kokura Hospital Keyword: 食道癌 , 肺癌 , 小腸GIST , 重複癌 , 同時性 pp.357-362
Published Date 2003/3/25
DOI https://doi.org/10.11477/mf.1403100885
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 The patient, a 65-year-old woman, suffered from an anemic condition and was admitted for detailed examinations. Upper gastrointestinal endoscopy revealed the presence of white blotches at the left posterior wall 30 cm from the incisor. The area resisted staining with iodine, showing an 0-IIa lesion. EMR was conducted. A histopathological examination revealed a squamous cell carcinoma with a depth of m1. A radiographic examination of the small intestine detected a submucosal tumor accompanied by a central ulcer that had developed about 5 cm extra-tubally in the ileum. The lesion was treated surgically. A diagnosis of gastrointestinal stromal tumor (GIST), combined with a smooth muscle-neural type with malignancy was made, based on the histopathological and immunohistochemical observations. A tumor image, measuring 18 mm at S 4 in the left lung field, was also detected from a presurgical thoracic CT. Lung cancer was suspected and the patient later underwent surgery. A histopathological examination led to a diagnosis of a highly differentiated papillary adenocarcinoma. There have been no reports of simultaneous development of three malignant tumors (esophageal and lung cancers and GIST of the small intestine). The present case represents a very rare incidence.

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