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Clinical Usefulness of Nutritional Treatment for Morphological Findings of Long-Standing Crohn's Disease―Especially Focusing on Comparison with Drug Treatment Kiyonori Kobayashi 1 , Tomoe Katsumata 1 , Masahiro Igarashi 1 1Department of Gastroenterology, Kitasato University East Hospital Keyword: Crohn病 , 長期経過 , 在宅経腸栄養療法 , 腸管合併症 pp.145-154
Published Date 2004/2/25
DOI https://doi.org/10.11477/mf.1403100427
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 We investigated the clinical usefulness of home enteral nutrition(HEN)to treat the morphological findings of long-standing Crohn's disease, especially focusing on comparison with drug treatment. Study subjects were80cases with Crohn's disease who had not undergone bowel resection at the time of their first visit to our hospital and who were followed up for more than5years by both radiography and colonoscopy. We mainly compared the therapeutic effects of HEN with those resulting from drug treatment in preventing the progression to intestinal complications, such as stenosis and fistula. Study subjects were divided into 2 groups, N group (51cases) and D group (29cases). The patients in N group were mainly treated by HEN and those in D group were treated by conventional drugs. The rate of progression to intestinal complications in the N group (17%) was significantly lower than that in the D group (45%). As regards clinical course, the mean number of hospitalizations and operations per patient-year were 0.14 and 0.07times in the N group, which were lower than those in the D group (0.22 and 0.13 times).

 Based on these results, it is concluded that continuous home enteral nutritional therapy is useful to prevent progression to intestinal complications and also to avoid surgical operations.

 1) Department of Gastroenterology, Kitasato University East Hospital, Sagamihara, Japan


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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