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Drug-induced Hemorrhagic Enterocolitis Nobuo Tomiyasu 1 , Osamu Tsuruta 1 , Keiichi Mitsuyama 1 1Department of Internal Medicine II, Kurume University School of Medicine Keyword: 薬剤性腸炎 , 出血性大腸炎 , 抗生物質起因性腸炎 , NSAIDs起因性腸炎 pp.611-615
Published Date 2005/4/25
DOI https://doi.org/10.11477/mf.1403100079
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 Drug-induced hemorrhagic enterocolitis is an erosive and ulcerative intestinal inflammation caused by drugs such as antibiotics or nonsteroidal anti-inflammatory drug (NSAID), and manifests as diarrhea and hematochezia. This disease includes acute hemorrhagic colitis and NSAIDs-induced enterocolitis. Acute hemorrhagic colitis is often seen in the proximal colon after the administration of antibiotics, which may be caused by allergic reaction, insufficient microcirculation and the alteration of microflora. NSAIDs-induced enterocolitis is observed in the whole intestine. The cause of the disease is probably based on NSAIDs-induced prostaglandin inhibition, which subsequently causes mucosal damage and enhances intestinal permeability. Because of the increasing use of such causative drugs, these two diseases will probably become more frequent in the future.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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