精神皮膚電流反応（GSR）の臨床的応用と其の知見

Some Observations on the clinical Application of Psychogalvanic Skin Pesponse (GSR)

I．緒言

　精神皮膚電流反応（以下GSRと略す）の中枢機構に関しては既に勝見^1）2）3）が猫を用いた実験的研究に於て，GSR支配の最も重要な中枢部位に視床ではなくして視床下部であり，且つ視床下部b交感帯の興奮はGSRの発現に対して促進的，c副交感帯の興奮は抑制的に作用する事を発表した。

　我々は之を基礎として癩癇患者に就いて其の発作時に於けるGSRを観察してpetit malの中枢機構を窺い，且つ自律神経遮断剤のGSRに及ぼす影響を検した。

M.Katsumi, one of the authors,already reported that the most important center go-verning GSR is the hypothalamus and not the thalamus on his experiments.

From these facts we observed the changes of GSR on cases of epilepsy and examined the effects of neuroplegic phenothiazine deri-vatives on GSR.

During the petit mal seizure, GSR was absent, while 3 per second spike and wave EEG pattern and "eye-lid-reflection" were seen at the time.

But at the postconvulsive period of non-res-ponsiveness induced by cardiazol, GSR was witnessed, though it was smaller than before.Accordingly we can assume that petit mal seizure may influence upon the hypothalamus intensively.

Among the phenothiazine derivatives, Chlor-promazine, which has the strongest sympa-thicomimetic action, could depress GSR in the strongest degree, and Promethazine ranked next, but Diethazine, which has the strongest parasympathicomimetic action, rather acce-lerated GSR a little.

So GSR measurement may be available to indicate the sympathicomimetic effects of such neuroplegics.