生活習慣病患者の急性期病態と栄養

Lifestyle-related Diseases and Nutrition : An Important Aspect of Calcium/Mineral Management. The nutrition of acute phase in patients with metabolic syndrome.

　生活習慣病患者が生じる急性期疾患としては，生活習慣病を既往歴に有するために発症率が高くなる心筋梗塞や脳梗塞のような疾患と，生活習慣病の増悪状態としての糖尿病ケトアシドーシスや高浸透圧性高血糖症候群など急性期病態が考えられる。こうした病態では様々な電解質異常が生じやすいが，中でもカルシウムは重症患者で低カルシウム血症が多く，死亡率を上昇させ，これに対するカルシウム投与の効果も報告されている。

　In this session, we describe the acute phase in patients with metabolic syndrome from two sides; acute disease that occurs higher in patients with metabolic syndrome such as colonary heart disease and stroke, and acute aggravation of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome. The electrolyte imbalance is frequently detected in critical ill patients. It is reported that the extreme abnormalities of ionized calcium concentrations are independent predictors of mortality. In addition, from clinical database MIMIC-Ⅱ，calcium supplementation improves clinical outcome in intensive care unit patients. Although metabolic syndrome; lifestyle-related disease, is a chronic disease, the possibility of falling into acute disease by having it becomes very high and improvement of electrolyte imbalance, especially hypocalcaemia is expected to effective on clinical outcome.