サルコペニアと動脈硬化

Transdisciplinary Approach for Sarcopenia. Sarcopenia and atherosclerosis.

　サルコペニアの病因は，動脈硬化の病因とも共通しており，サルコペニアと動脈硬化には関連性がある。我々の検討でも，サルコペニア，特に内臓肥満を合併した男性のサルコペニア肥満において脈波伝搬速度や中心血圧が上昇していた。サルコペニア，サルコペニア肥満はレプチン抵抗性も亢進しており，動脈硬化の要因となっている可能性がある。疫学研究においてもサルコペニア指標は心血管死と関連している。サルコペニアは，動脈硬化，心血管リスクとしても捉える必要があると考えられる。

　Risk factors for sarcopenia, including aging, inflammation, oxidative stress, and sedentary life style, are also known as risks for atherosclerosis. Sarcopenia and atherosclerosis relate each other. We found that sarcopenia, especially sarcopenic visceral obesity in male subjects, was associated with higher arterial stiffness and central blood pressure. We also observed that leptin resistance may underlie the link between sarcopenia, sarcopenic obesity and atherosclerosis. In epidemiological studies, it has been demonstrated sarcopenic indices were associated with cardiovascular death. These findings indicate that sarcopenia could be regarded as risk factor for atherosclerosis and cardiovascular events.