専門施設におけるCOVID-19患者の概要と治療経過：1-7波を通じて

Treatment and Outcome of 2,215 COVID-19 Patients in a Specialized Hospital in Osaka

要旨

　当病院で治療を行ったコロナウイルス感染症患者2,215名について検討した。症例は男女ほぼ同数で，年齢の中央値は68歳，入院時の重症度は軽症，中等症Ⅰ，中等症Ⅱ，重症がそれぞれ34％，42％，22％，2％であった。89％は改善後に退院したが，6％は呼吸状態が増悪，4％は死亡した。増悪因子として，高齢，男性，糖尿病の合併，入院時のリンパ球減少，乳酸脱水素酵素，C反応性タンパクの上昇が示唆された。

　We reviewed retrospectively the characteristics, treatment and outcome of 2,215 patients（male 1,138 and female 1,077；median age 68 years）from March 2020 to August 2022 in our hospital. Severity scales on admission were mild, moderate Ⅰ, moderate Ⅱ and severe, each 744（34％）, 941（42％）, 493（22％）and 37（2％）among the patients, respectively. Major symptoms on admission were cough, general fatigue, fever≥37.5°C, but no dyspnea. Commonly observed comorbidities were hypertension（36％）and diabetes mellitus（20％）. They received antivirus and monoclonal antibody medication in addition to oxygen therapy, including nasal high flow oxygen administration. Respiratory condition recovered in 1,971（89％）and bacome worse in 123（6％）patients who were transferred to advanced hospitals；and 93 patients（4％）died. Factors related to deterioration of the condition were：advanced age, male sex, diabetes mellitus, decreased lymphocyte count, increased serum lactate dehydrogenase and C-reactive protein levels on admission.