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早期膀胱癌に対する治療として,1970年代よりbacille Calmette-Guérin(BCG)膀胱内注入療法が施行されている.本治療は効果が高く,一般的に安全であると評価されている1).しかしまれではあるが合併症も認められ,その中には感染性動脈瘤の報告もある2~4).われわれは,BCG膀胱内注入療法後に急速拡大をきたした感染性胸部大動脈瘤に対して,胸部ステントグラフト内挿術(TEVAR)を施行した2例を経験したので報告する.
Bacille Calmette-Guérin (BCG) intravesical therapy is an effective and safe treatment for bladder cancer;however, mycotic aneurysms have been reported as a rare complication.
Case 1:A 64-year-old man with a history of BCG intravesical therapy underwent emergent thoracic endovascular aortic repair (TEVAR) for a ruptured thoracic aortic aneurysm (TAA). He was diagnosed with BCG infection by hemosputum specimen culture five months later;then, antituberculous therapy was initiated. However, his follow-up computed tomography scan revealed stent-graft infection and new aneurysm formation. Therefore, we performed a repeated TEVAR with abdominal 4-vessel debranching. There was no recurrence of infection for six years while continuing postoperative antituberculous therapy.
Case 2:A 72-year-old man who had undergone BCG intravesical therapy underwent TEVAR for a rapidly enlarging mycotic TAA. He received anti-tuberculous therapy for one year with no recurrent infection for one year. TEVAR may be an effective alternative to the open surgical procedure;however, multidisciplinary treatment including anti-tuberculous therapy and careful long-term follow up are required.
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