Japanese

Dynamic Changes of Urinary Glycoproteins and Their Relation to Psychoneurological Diseases Tadahiro Shikimi 1 1Department of Pharmacology, Shimane Medical University Keyword: 精神神経疾患 , アルファ-1-ミクログロブリン , ウリナスタチン , Psychoneurological diseases , Alpha-1-microglobulin , Ulinastatin pp.1-5
Published Date 2000/12/25
DOI https://doi.org/10.11477/mf.7009200146
  • Abstract
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Abstract

 In humans, two glycoproteins, alpha-1-microglobulin(α1M)and ulinastatin(UT), are excreted in urine. Dynamic changes of these two substances in urine differ with psychoneurological diseases: The slope in the regression line showing the relation between urinary contents of α1M and UT did not differ between the schizophrenia group and healthy controls. However, the respective slopes of dementia and major depression groups were significantly(p<0.05)more inclined than those of relevant control groups. These results suggest that the relationship between urinary contents of α1M and UT in dementia and major depression groups differs from that of healthy subjects. As for Parkinson's disease group, a correlation between urinary contents of α1M and UT was not established. The respective contents of α1M and UT in dementia, schizophrenia, major depression and Parkinson's disease groups did not differ from those of respective controls. Thus, the relation between urinary contents of α1M and UT, but not the contents per se, was found to vary with psychoneurological diseases. Examination of the urinary contents of α1M and UT in noninvasively collected urine specimens would provide useful information on psychoses and neurodegenerative diseases in humans.


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電子版ISSN 印刷版ISSN 1345-2606 日本看護医療学会

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