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Secondary immunodeficiencies:classification and evaluation(from an intensivist point of view) Hiroshi OONO 1 1Intensive Care Medicine, Rakuwakai Otowa Hospital pp.589-606
Published Date 2023/10/1
DOI https://doi.org/10.11477/mf.3102201123
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Secondary immunodeficiency (SID) should be considered in a patients with infections characterized by increased frequency, need of parenteral antibiotics, unusual severity, difficult recovery, or uncommon etiological pathogens. SID is pathophysiologically classified as i) phagocytosis dysfunction, ii) cellular immunodeficiency, iii) humoral immunodeficiency, and iv) disruption of the skin and mucosal barriers. Chronic medical illnesses, such as diabetes mellitus, chronic obstructive pulmonary disease, chronic kidney disease, cirrhosis, and heart failure, are often associated with SID, that makes affected patients prone to specific life-threatening infections. The appropriate management of severe infection in these SID patients is i) an early diagnosis, ii) administration of appropriate antibiotics, iii) provision of general supportive care, and iv) immunomodulation therapy (if indicated).


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電子版ISSN 2186-7852 印刷版ISSN 1883-4833 メディカル・サイエンス・インターナショナル

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