Diabetes mellitus and genetic analysis Hiroshi Onuma 1 , Haruhiko Osawa 1 1Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine Keyword: 一塩基多型 , 感受性遺伝子 , ゲノムワイド関連解析(GWAS) pp.1677-1681
Published Date 2010/12/15
DOI https://doi.org/10.11477/mf.1542102497
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Diabetes mellitus is a polygenic disease associated with common genetic variants and environmental factors. Recently, genome wide association studies (GWAS) have revealed more than 20 susceptible loci for type 2 diabetes mellitus and many of them were replicated in Japanese population. However, these variants identified by GWAS had low odds ratio between 1.1-1.5 suggesting low penetrance of these variants. Further approach to identify rare variants with higher penetrance and CNV associated with diabetes mellitus will be needed.

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