Roles of Urothelium in Micturition Isao Araki 1,2 , Hiroshi Nakagomi 1 , Tsutomu Mochizuki 1 , Hideki Kobayashi 1 , Mitsuharu Yoshiyama 1 , Masayuki Takeda 1 1Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering 2Department of Urology, Shiga University of Medical Science Keyword: 尿路上皮 , 膀胱知覚 , イオンチャネル pp.726-730
Published Date 2010/7/15
DOI https://doi.org/10.11477/mf.1542102332
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Recently, the bladder epithelium has been shown to play an important role in mechanosensory transduction. A variety of mediators, such as ATP, are released from urothelium in response to bladder distention. Multiple receptors and ion channels including TRP and ENaC/degenerin channel families expressed in urothelial cells are involved in this stretch-evoked mediator release. ATP released from bladder epithelial cells acts on P2X3 receptors located in the subepithelial afferent nerve plexus.

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