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ALLERGIC RHINITIS AND HLA Kimihisa Nomura 1 pp.683-689
Published Date 1979/9/20
DOI https://doi.org/10.11477/mf.1492208951
  • Abstract
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 Population study of HLA was performed in 58 cases of allergic rhinitis to dust or pollen. There was a significant increase in the incidence of BW22 including BW54 in allergic rhinitis group (N=58, 20.7%) compared with the healthy adults (N=355, 11.0%) (p <0.05). A further subdivision of these patients into age of onset, causative antigen, ill season, personal history of bronchial asthma and family history of the allergic rhinitis was made. In the children who had been suflering from the disease since less than ten years old, the incidence of BW22 was significant (N=18, p<0.005) to the healthy adults. But even this group showed no significance in corrected p value.

 A large family comprising 24 individuals, nine allergic to dust and/or Japanese cedar pollen, was examined. Among five persons whose skin tests were positive to house dust and had perennial symptoms, AW24-BW54 haplotype was found in four. Except for them, none of other family members had the same haplotype. Radioallergosorbent test (RAST) to Dermatophagoides farinae and D. pteronyssinus was made to all individuals. Five were positive to the RAST and three of them had AW24-BW54. From these results a close correlation between house dust allergy and this haplotype was suspected. Detection of DR locus in this family were not successful.


Copyright © 1979, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 印刷版ISSN 0386-9679 医学書院

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