Osler氏病症例

OSLER'S DISEASE, A CASE REPORT

　I．緒言

　末梢血管拡張と出血傾向と遺伝性とを三主徴候とする遺伝性出血性末梢血管拡張症（Hereditary-Hemorrhagic-Telangiectasia）は一般にOsler氏病とよばれている。1901年，Osler^1）によつて詳細に記載されたものであるが，遺伝性鼻出血のような非典型的なものについてはそれ以前にも報告者があるので，本症はまたRendu-Osler-Weber氏病ともよばれている。欧米では数多くあるが，本邦では稀な疾患とされていた本症が近年，特に耳鼻咽喉科医によつてあいついで報告され漸く注目されるようになつてきた。

　A woman, aged 36, who appeared to be quite well until she reached the age 32, when she deveolped repeated hemotaxis. And, since an year ago she developed bleeding from the tongue and lips as well as patches of facial vascular discolorations.

　The diagnosis of Osler's disease was made. Typical blotches were recognized on the nasal mucous membrane. Retinoscopy was not performed.

　The patient was treated by estrogen therapy, 1 or 2 intravenous dose per week, with a considerable improvement of symptoms. Two months later after continuous treatment the patient began to develop reactionary symptoms when the medication was discontinued. The patient died 3 years later in another hospital.