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Japanese

Treatment of metastatic brain tumors from lung cancer:analysis of performance status between treatment methods Hidemitsu NAKAGAWA 1 , Yasushi HAGIWARA 1 , Masanobu YAMADA 1 , Shusuke MORIUCHI 1 , Koichi IWATSUKI 1 , Shinichiro NAKAMURA 2 , Takeshi HOURAI 2 1Department of Neurosurgery, Osaka Medical Center for Cancer & Cardiovascular Diseases 2The IVth Internal Medicine, Osaka Medical Center for Cancer & Cardiovascular Diseases Keyword: metastatic brain tumor , lung cancer , performance status pp.117-122
Published Date 1997/2/10
DOI https://doi.org/10.11477/mf.1436901342
  • Abstract
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Retrospective analysis was peformed in 280 patients;112 surgical cases and 168 non-surgical cases to deter-mine which of three treatments, alone or in combina-tion provides more prolonged improvement of perform-ance status (PS:Karnofsky score) in patients with metastatic brain tumors from lung cancer. The treat-ments under scrutiny were surgical removal of metasta-tic brain tumor (5), radiation therapy (R) and che-motherapy (C). KS in the group treated with S or C showed a significantly better result than that in the non-S group or non-C group during the two-year observation period. However, R group showed no signi-ficant improvement in KS compared to that in the non-C group during the two-year period. During the first year after admission, two subgroups of S plus R and R alone showed most rapid decrease in KS. However, subgroups of S plus C and S plus R and C showed bet-ter results than other subgroups. In analyzing the changes in KS over the short period from admission to one month after treatment had been completed, the non-S group showed a significant decrease in KS, while the S group showed a slight increase in mean KS. The subgroup of R alone showed the greatest decrease in KS. Thus, retrospective analysis showed that surgical removal of a metastatic brain tumor led to improved KS for a short period and chemotheapy was useful in prolonging the duration of better Q.O.L.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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