雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Histogenesis of Central Neurocytoma:an immunohistochemical and electronmicroscopic study of four cases Jiro AKIMOTO 1 , Hiroshi ITOH 1 , Yoshinori ITOH 2 , Tetsuro MIWA 3 1Department of Neurosurgery, Tokyo Medical College 2Department of Neurosurgery, Tokyo Medical College Kasumigaura Hospital 3Department of Neurosurgery, Kosei Chuo Hospital Keyword: Central neurocytoma , Synaptophysin , Neuronal differentiation , Glial differentiation pp.1083-1091
Published Date 1995/12/10
DOI https://doi.org/10.11477/mf.1436901125
  • Abstract
  • Look Inside

Four intraventricular central neurocytomas were stu-died histopathologically and intriguing findings were obtained with regard to the histogenesis of this tumor. The cases included 3 males and 1 female aged 17-25. The tumors had developed in the regions from the lateral to the third ventricles and were surgically re-moved in all the cases.

A honeycomb appearance was recognized on H & E staining, and the calcification and latticed vascular find-ings closely mimicked the appearance of oligodendro-glioma. A characteristic wide eosinophilic fibrous stro-ma was observed frequently. Immunohistochemically, all four cases were NSE-positive and strongly synaptophysin-positive, and by electronmicroscopy, neurosecretory granules and micro-tubules were observed in all cases and typical synapse structures in 2 cases. GFAP immunoreactivity and glial differentiation, including ependymal cells were exhi-bited electronmicroscopically, such as glial fibrils, basal bodies, centrioles and 9+1 patterned cilia-like struc-tures in 2 cases.

These findings suggest that central neurocytoma is an embryonal tumor in the wide sense, originating from the germinal matrix cell of the lateral ventricles and possessing multipotency, with potent differentiation from mature neurons.


Copyright © 1995, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

関連文献

もっと見る

文献を共有