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A Case of an Intracerebral Mass Lesion Consisting of Traumatic Granulation Tissue Masahiko WANIBUCHI 1 , Teiji UEDE 1,3 , Masanori ISHIGURO 1 , Koshi TATEWAKI 1 , Yasutaka KUROKAWA 1 , Yutaka YOSHIDA 2 1Department of Neurosurgery, Kushiro City General Hospital 2Division of Pathology, Kushiro City General Hospital Keyword: Brain edema , Brain neoplasms , Granulation tissue , Trauma pp.963-966
Published Date 1994/10/10
DOI https://doi.org/10.11477/mf.1436900920
  • Abstract
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We reported a rare case of an intracerebral granulo-matous lesion accompanying severe edema formation in the healing stage of traumatic brain contusions.

A 44-year-old male patient came to our outpatient cli-nic due to progressing headache and nausea. Upon computed tomographic examination, a low density mass with strong surrounding edema was detected at the right frontal base. Magnetic resonance images revealed a high intensity mass on both T1- and T2-weighted im-ages at the right frontal base. Upon intravenous injec-tion of a contrast agent, this lesion exhibited multifocal marginal contrast enhancement. Two additional small enhanced mass lesions were detected at the tip of the right temporal lobe and the medial portion of the left temporal lobe. We tentatively diagnosed it as a right frontal brain tumor and attempted the total removal of the right frontal mass. Unexpectedly, pathological dia-gnosis was intracerebral granulation tissue associated with accumulation of hemosiderin-laden macrophages and capillary wall thickening. In addition, there was no reactive gliosis.

We speculated on the pathogenesis of intracerebral granulation tissue as follows. Since the patient was a heavy drinker and often fell down when he was drunk, it is likely that he might be suffering from intracerebral hematomas due to traumatic contusions. This assump-tion may be supported by the fact that an old subdural hematoma was observed during the operation and the radiological examination revealed multiple lesions. The gathering and proliferation of mesenchymal cells pos-sibly derived from blood circulation probably began at the site of the damaged brain tissue, thus forming in-tracerebral granulation tissue.

To avoid an unnecessary operation, it is important to watch the development of an intracerebral mass lesion when we suspect it may be of traumatic origin.


Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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