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A Case of Aspergillosis Presenting Marked Granulomatous Pachymeningitis Junichi IIDA 1 , Kiyoshi TAKEMURA 1 , Yasumasa MAKITA 2 1Department of Neurosurgery, Ishinkai Yao Hospital 2Department of Neurosurgery, Yamato Neurosurgical Hospital Keyword: Aspergillosis , Granulomatous pachymeningitis , Septic cerebral embolism pp.491-494
Published Date 1994/5/10
DOI https://doi.org/10.11477/mf.1436900844
  • Abstract
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The authors report a rare case of intracranial asper-gillosis presenting marked granulomatous pachymenin-gitis.

A 58-year-old male who had a three-year history of diabetes and chronic bronchitis was referred to us be-cause of progressive left hemiparesis and dysarthria. Postcontrast CT scan showed a ring-enhancing lesion with marked perifocal edema in the right parietal lobe, and right subdural enhancing mass. MR image revealed hypertrophic dura mater in the right convexity.

On June 9, 1992, partial removal of the intra-axial cystic mass and granulomatous dura mater was per-formed. A number of characteristic aspergillus hyphae were recognized in the resected cyst and granulomatous dura mater. Postoperatively, the patient was treated with amphotericin-B and fluconazole. But granuloma-tous pachymeningitis became progressively enlarged and eventually created a large mass effect again. On January 23, 1993, the patient died of pneumonia.

Cerebral aspergillosis is getting common but preop-erative diagnosis is still difficult because of its causing several clinical features such as brain abscess, granulo-ma, intracerebral hemorrhage, cerebral infarction, meningitis, and encephalitis.

Several comments were made about the pathogenesis of these features, and the necessity of early diagnosis and treatment was emphasized.


Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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