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Measurements of CSF Biochemical Tumor Markers in Patients with Meningeal Carcinomatosis Hidemitsu NAKAGAWA 1 , Shigeki KUBO 1 , Akira MURASAWA 1 , Shin NAKAJIMA 1 , Yoshikazu NAKAJIMA 1 , Shuichi IZUMOTO 1 , Toru HAYAKAWA 2 1Department of Neurosurgery, The Center for Adult Diseases, Osaka 2Department of Neurosurgery, Osaka University Medical School Keyword: Brain tumor , Meningeal carcinomatosis , CSF , Tumor marker pp.1135-1141
Published Date 1991/12/10
DOI https://doi.org/10.11477/mf.1436900365
  • Abstract
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CSF β-glucuronidase, polyamines and carcinoem-bryonic antigen (CEA) were analyzed in 16 patients with meningeal carcinomatosis from solid tumors in systemic organs, 27 with benign brain lesions, 11 with primary brain tumors, 14 with metastatic brain tumors and 5 with leptomeningeal dissemination of other malignant diseases. β- glucuronidase levels in all cases of meningeal carcinomatosis, meningeal gliomatosis and meningeal lymphoma were higher than 100μg/dl/hr. On the other hand, levels in all cases of benign brain lesions were below 100μg/dl/hr. Levels of β-glucu-ronidase in the cases of metastatic brain tumors returned to normal levels after tumor resection. Levels of β-glucuronidase and polyamines were not high in the cases with positive cytology in CSF after tumor resec-tion. The polyamine level seemed to be dependent on the growth rate of the disease and was shown to be be-low 0.05nmol/ml in all cases after resection of the metastatic brain tumors. Cystic fluid of both benign and malignant tumor showed high levels of β- glucuroni-dase and polyamines except for spermidine and sper-mine levels in a suprasellar cyst. Some cases of menin-geal carcinomatosis with high levels of serum CEA did not always show high levels of CSF CEA. In the sur-gical cases with a metastatic brain,tumor, the cases with leptomeningeal, especially dural attachment showed high levels of β-glucuronidase and CEA preoperatively, but they returned to normal after surgery. In 2 cases of meningeal carcinomatosis treated by intrathecal chemotherapy with MTX and Ara-C, CSF β-glucuronidase and CEA showed clinical con-dition better than the cell count in CSF decreased rapidly following chemotherapy.

β-glucuronidase was considered to be a useful CSF marker in the cases of meningeal carcinomatosis to monitor the course of the disease, and CEA was also considered to be a useful marker when CEA levels in CSF are higher than those in serum.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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