Neurological Surgery No Shinkei Geka Volume 46, Issue 3 (March 2018)

Computational Fluid Dynamic Analysis of Intracranial Aneurysms Using Newly Developed Software:Can It Predict the Thin-Walled Region of Intracranial Aneurysm Preoperatively? Emiko HORI 1 , Kimiko UMEMURA OYA 1 , Satoshi HORI 1 , Soshi OKAMOTO 1 , Takashi SHIBATA 1 , Michiya KUBO 1 , Yukio HORIE 1 , Masaki KOH 2 , Daina KASHIWAZAKI 2 , Satoshi KURODA 2 1Department of Neurosurgery, Saiseikai Toyama Hospital 2Department of Neurosurgery, Faculty of Medicine, University of Toyama Keyword: cerebral aneurysm , computational fluid dynamics , pressure , wall shear stress pp.199-206
Published Date 2018/3/10
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 OBJECT:Recent studies have shown that computational fluid dynamics(CFD)analysis is useful to evaluate flow dynamics of intracranial aneurysms. However, CFD analysis still requires high costs and substantial time even now. This study aimed to evaluate whether newly developed software can shorten the time for analysis and serve useful information during clipping surgery for intracranial aneurysms.

 METHODS:CFD analysis was performed in 55 unruptured cerebral aneurysms in 51 patients. The time required for analysis of each aneurysm was recorded. On the basis of CFD analysis, both pressure and wall shear stress(WSS)were calculated as the values at the systolic and diastolic phases, and also the mean value through one cardiac cycle. These data were compared between thin-wall points and other points within each aneurysm.

 RESULTS:The average time required for analysis was 3 hours, ranging from 1 to 15 hours. The CFD data could be referenced during surgery in each patient. The pressure in about 93% and 80% of the thin-wall points was higher than that at other points within each aneurysm in the systolic and diastolic phases, respectively. However, there was no significant correlation between WSS and wall thickness in each aneurysm.

 CONCLUSION:This study clearly shows that newly-developed software is simple and requires much shorter time for CFD analysis than previous methods. Higher pressure through the cardiac cycle may efficiently predict a thin-wall region within intracranial aneurysms, which strongly suggests that CFD analysis would be a valuable tool to determine the treatment strategy in patients with unruptured aneurysms.

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Neurological Surgery 脳神経外科
46巻3号 (2018年3月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院