妊娠初期に静脈洞血栓症を発症した先天性プロテインC欠損症の1例

A Case Report of Congenital Protein C Deficiency with Cerebral Venous Sinus Thrombosis during Early Pregnancy Period

Ⅰ．はじめに

　今回われわれは，妊娠初期に上矢状静脈洞血栓症を発症した症例を経験した．その後の血液検査で先天性プロテインC欠損症が確認され，家族歴も明らかとなった．妊娠中の先天性プロテインC欠損症に併発した脳静脈洞血栓症の報告は2例目と考えられ¹⁾，若干の文献的考察を加えて報告する．

　A 35-year-old woman at eight weeks of gestation in her second pregnancy presented with generalized seizures. Magnetic resonance images revealed a small hemorrhagic infarction in the left frontal lobe, and magnetic resonance venography indicated cerebral venous sinus thrombosis. After hospitalization, anticoagulant therapy was continued, and a low protein C level was confirmed, which was also confirmed in both her mother and her sister. Follow-up magnetic resonance venography performed on day 27 confirmed that the cerebral venous sinuses had undergone recanalization. After a completed gestation period, the patient gave birth to healthy girl uneventfully.