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Japanese

Experimental Study of Protective Effect on Cerebral Ischemia of Various Antioxidants and Other Agents: With special reference to the combined treatment of mannitol, vitamin E, dexamethasone and perfluorochemicals Shunichi FUJIMOTO 1 , Kazuo MIZOI 1 , Masatoshi OBA 1 , Jiro SUZUKI 1 1Division of Neurosurgery, Institute of Brain Diseases,Tohoku University School of Medicine Keyword: Cerebral protective substance , Free radical scavenger pp.171-180
Published Date 1984/2/10
DOI https://doi.org/10.11477/mf.1436201786
  • Abstract
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 We have previously reported that the combinedadministration of mannitol and perfluorochemicalblood substitutes is evidently effective in protectingthe brain from cerebral ischemia. This experimentalstudy was designed to develop more effective methodin suppressing brain infarction than the combinedtreatment of mannitol and PFC.

 Using the "Canine model of complete ischemicbrain regulated with a perfusion method" in whichit is possible to control the degree of blood flow to acerebral hemisphere via a perfusion pump, the effectof eight agents including six kinds as the free radicalscavenger on cerebral ischemia was investigated.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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