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Japanese

Ion-beam Irradiated ePTFE for the Therapy of Intracranial Aneurysms Tasuku YOTORIYAMA 1 , Hiroshi UJIIE 2 , Noriyoshi TAKAHASHI 1 , Yoko ONO 3 , Yoshiaki SUZUKI 4 , Masaya IWAKI 4 , Tomokatsu HORI 2 1Graduate School,Tokyo University of Science 2Department of Neurosurgery,Neurological Institute,Tokyo Women's Medical University 3Faculty of science,Tokyo University of Scinece 4Beam Application Team,Advanced Develpment and Supporting Center,RIKEN Keyword: cell migration and adhesion , wrapping material , in vivo study , aneurysm wrapping pp.471-478
Published Date 2004/5/1
DOI https://doi.org/10.11477/mf.1436100384
  • Abstract
  • Look Inside

 Intracranial aneurysms are frequently treated with either microsurgical clipping or endovascular coiling. However,as so called broad-neck aneurysms are not suitable for these treatment options,a wrapping technique using muslin gauze,muscle piece,ePTFE is applied for such cases. The material for aneurysmal wrapping demands both stable adherence and no reactive inflammatory response such as inert artificial wall. Authors have developed a new improved ePTFE by ion-beam irradiation technique that is biologically inert and able to adhere firmly to surrounding tissue. Based on the last studies,Ar+ ion at an energy of 150 keV with a fluence of 5×1014 ions/cm2 was chosen to irradiate ePTFE. A cell adhesion test and direct implantation of ion-beam irradiated ePTFE as wrapping material to rabbit common carotid arteries (CCA) were examined. It was demonstrated that the surface of ion-beam irradiated ePTFE exhibits remarkably greater adhesion and promotes cell proliferation on the surface more effectively than that of non-irradiated ePTFE. The carotid artery well-wrapped by ion-beam irradiated ePTFE strongly adhered to the mural wall and induced little inflammatory reaction. The results of this investigation indicate that application of this technology would offer the best means for aneurysm wrapping.


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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