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GTP-binding proteins and signal transduction. Shin-ichi HOSHINO 1 , Michio UI 1 1Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo pp.919-925
Published Date 1989/12/10
DOI https://doi.org/10.11477/mf.1431906344
  • Abstract
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GTP-binding proteins are a family of membrane-bound guanine nucleotide binding proteins which play key roles in transduction of extracellular signals given to cell surface receptors to membrane effectors producing intracellular signals. The mechanism of signal transduction by the proteins in best characterized in the adenylate cyclase system and for transducin, the G protein in retina. Recent progress in molecular characterization of G proteins revealed occurrence of at least 9 distinct entities of molecule in mammals. Since most of the mammalian cells contain multiple G proteins with structural similarities, a current problem is to explain how specificity is achieved among the different proteins.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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