雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Feedback loop of clock genes Hitoshi OKAMURA 1 , Satoru MASUBUCHI 1 , Naoyuki ICHIHARA 1 , Shun YAMAGUCHI 1 1Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine Keyword: mPer , 転写制御 , フィードバックループ , 時計遺伝子 pp.755-762
Published Date 2001/10/10
DOI https://doi.org/10.11477/mf.1431901467
  • Abstract
  • Look Inside

Transcription- (post) translation feedback loop of a set of clock genes generate circadian oscillation in many organisms. Recently, it was elucidated an accessory transcription loop helping the oscillation of the core clock feed-back loop. Cyclic expression of PAR proteins activates the promoter of a clock oscillating gene, mPer1, by directly binding to the mPer1 promoter. PAR protein and CLOCK-BMAL1 cooperatively activated the mPer1 promoter. E4BP4 negatively regulates mPer1 transcription by the competence to the same binding site of PAR proteins loop. The core and accessory loop may also be useful for transmitting time of core oscillator to clock controlled genes.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

関連文献

もっと見る

文献を共有