Pleiotropic effects of hepatocyte growth factor (HGF) in the central nervous system. Mitsuru MACHIDE 1 , Shinichi KOHSAKA 1 1Department of Neurochemistry, National Institute of Neuroscience, NPNC Keyword: 肝細胞増殖因子 , HGF , 神経栄養因子 , 細胞内シグナル伝達 pp.423-433
Published Date 2000/6/10
DOI https://doi.org/10.11477/mf.1431901159
  • Abstract
  • Look Inside

Hepatocyte growth factor (HGF) has been initially characterized as a pleiotropic factor in peripheral organsand cells. However accumulating lines of evidence indicated that HGF functions as a neurotrophic factor in thecentral nervous system. Here we first introduced recent findings on neurotrophic effects of HGF on developingspinal neurons. Secondly, we showed on the basis of our own studies that HGF promotes neurite-outgrowth of embryonic rat neocortical explants and chemokinetic migration of primary astrocytes. Concerning the biochemicalmechanisms for the diverse effects of HGF on these cells, we showed that differential activation of phospholipaseCγ1 (PLCγ1) and phosphatidylinositol 3 (PI3)-kinase is a critical intracellular event. Furthermore, we discussedabout an involvement of the tyrosine phosphatase, SHP-1, in the selective activation of either PI3-kinase orPLCγ1 in astrocytes.

Copyright © 2000, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院